0094. Monocyte tace activity profile during sepsis and systemic inflammatory response syndrome

Introduction To date, immune-modulatory treatments in sepsis have proved unsuccessful. Better understanding of inflammatory processes might help tailor such therapies more effectively and improve their efficacy. It is now recognised that some patients may require immune stimulating therapies. Monocytes display altered behaviour in response to systemic inflammation; this has been called “deactivation” and is characterised by reduced HLA-DR expression and attenuated tumour necrosis factor-a (TNF) release in response to lipopolysaccharide (LPS) stimulus. TNF converting enzyme (TACE), activated via p38-mitogen activated protein kinase (MAPK) mediated pathway, is essential for the shedding of TNF and TNF receptors (TNFRs)-1&2. Altered TACE behaviour may be mechanistically important in deactivation.